This is an excellent piece of commentary by Carl Heneghan and colleagues with the above title.
Open access: YES
Published: 14 Mar 2017
Fig. 1 Why clinical trial outcomes fail to translate into benefits for patients
The authors listed the above reasons why clinical trials may fail to translate beneficially for patients in the clinic. And it covers a range of issues from design flaws to poor methodology, problems such as publication bias and poor interpretation of data.
And they go through each one of them in this article. It’s a great piece to enlighten us of the many limitations that a clinical trial may have, especially when they are not done well. As clinicians we need to be able to spot these limitations as we critically appraise journal articles so that we may accurately interpret the results of the study.
Please click on the link below to read the full article: